CJC-1295
Tetrasubstituted 29-amino-acid peptide with Drug Affinity Complex (DAC)
The long-acting GHRH for sustained growth hormone release and systemic benefits.
CJC-1295 is a synthetic analogue of Growth Hormone Releasing Hormone (GHRH) modified with a Drug Affinity Complex (DAC). This modification dramatically extends its half-life, allowing it to stimulate the pituitary gland for days after a single administration. It's renowned in research for its ability to create a sustained elevation in both Growth Hormone (GH) and Insulin-like Growth Factor 1 (IGF-1) levels.
Key Benefits
Mechanism of Action
CJC-1295 binds to GHRH receptors on the anterior pituitary gland, triggering the synthesis and release of endogenous growth hormone. Unlike native GHRH, the attached DAC moiety allows it to bind to serum albumin, protecting it from rapid degradation. This results in a prolonged, stable increase in GH levels, leading to a consistent elevation of IGF-1, the primary mediator of GH's anabolic effects.
Dosing Guidelines
Typical Dose
500-1000 mcg
Frequency
1-2x per week
Duration
12-16 weeks
Note: Administer via subcutaneous injection. Best taken on an empty stomach or before bed to maximize the natural GH pulse during sleep. The long half-life means daily injections are unnecessary.
Research & Studies
A comprehensive overview of how CJC-1295 with DAC works to elevate growth hormone and IGF-1 levels for long-term benefits.
Read Full ResearchClinical trial results demonstrating the extended half-life and significant, dose-dependent increases in GH and IGF-1 in healthy subjects.
Read Full ResearchExplores the rationale behind combining a GHRH with a GHRP to achieve a more potent and effective release of growth hormone.
Read Full ResearchPotential Side Effects
Reported side effects may include:
- • Temporary flushing and head rush sensation post-injection
- • Water retention, particularly in the first few weeks
- • Tingling or numbness in hands/feet (mild carpal tunnel symptoms)
- • Increased fatigue or lethargy
- • Injection site redness, soreness, or itching
- • Potential for temporary increase in blood glucose
This information is for research purposes only. Always consult with a healthcare professional.
Popular Stacking Options
CJC-1295 + Ipamorelin
Ipamorelin provides a strong, clean GH pulse that works synergistically with CJC-1295's sustained elevation of GH levels, maximizing overall output without significantly affecting cortisol or prolactin.
Shop this stackCJC-1295 + Tesamorelin
Stacking two different GHRH analogues can amplify the signal to the pituitary. This combination is particularly researched for visceral fat reduction.
Shop this stackCJC-1295 + BPC-157
While CJC-1295 provides systemic healing via elevated IGF-1, BPC-157 offers targeted, localized repair mechanisms, creating a powerful combination for injury recovery.
Shop this stackFrequently Asked Questions
What's the difference between CJC-1295 with DAC and without DAC (Mod GRF 1-29)?
The key is the half-life. CJC-1295 with DAC lasts for about a week, so you only inject it 1-2 times per week for a sustained GH 'bleed'. Mod GRF 1-29 (CJC without DAC) has a half-life of only 30 minutes, requiring multiple daily injections to create GH 'pulses'. For sustained, long-term elevation, the DAC version is far more practical.
Will CJC-1295 'shut down' my natural GH production?
No, it doesn't cause shutdown in the same way anabolic steroids affect testosterone. CJC-1295 works by stimulating your own pituitary gland to produce more GH, not by introducing an external hormone. It enhances your natural system, and production returns to baseline after discontinuation.
When is the best time to inject CJC-1295?
Most protocols suggest injecting before bed. This timing leverages your body's largest natural GH pulse, which occurs during deep sleep, potentially amplifying the effects. Injecting on an empty stomach is also recommended, as fats and carbohydrates can blunt GH release.
How long does it take to see results from CJC-1295?
Effects are gradual. Improved sleep and recovery can be noticed within the first couple of weeks. Noticeable changes in body composition, like fat loss and muscle fullness, typically become apparent after 4-6 weeks of consistent use, with more significant results seen after 12 weeks.
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