Best Peptide Stacks | Wolverine Stack, GH Blast, Fat Loss & More | Potent Peptide
PotentPeptide
20 curated protocols

Peptide Stack Guide

Proven peptide combinations for specific goals. Each stack includes exact dosing, duration, cost estimates, and the science behind why these peptides work together.

The Wolverine Stack

BPC-157 + TB-500

strong evidence

The most popular recovery stack in the peptide community. Combines BPC-157's targeted local healing with TB-500's systemic tissue repair for comprehensive injury recovery. Named after the X-Men character for its association with rapid regeneration.

Goal: Maximum injury recovery & tissue repair
Duration: 4-8 weeks
Cost: $40-80/week

Protocol

Peptide Dose Frequency
BPC-157 250-500 mcg/day 1-2x daily
TB-500 2-2.5 mg 2x weekly

Benefits

  • Accelerated tendon/ligament healing
  • Reduced scar tissue
  • Faster return from injury
  • Synergistic local + systemic repair
  • Anti-inflammatory effects

Best For

Tendon/ligament injuries Post-surgical recovery Chronic joint issues Athletes returning from injury
Note: BPC-157 is injected subcutaneously near the injury site for targeted healing, while TB-500 can be injected anywhere as it works systemically. Many users report noticeable improvement within 2-3 weeks.

The GH Blast Stack

Ipamorelin + CJC-1295

strong evidence

The gold-standard growth hormone stack. Combines a GHRP (Ipamorelin) with a GHRH analog (CJC-1295 no DAC) for synergistic GH release that far exceeds what either peptide achieves alone. The selectivity of Ipamorelin means no cortisol or prolactin spikes.

Goal: Maximum natural growth hormone release
Duration: 8-12 weeks
Cost: $30-60/week

Protocol

Peptide Dose Frequency
Ipamorelin 200-300 mcg 2-3x daily
CJC-1295 (no DAC) 100-200 mcg 2-3x daily (with Ipamorelin)

Benefits

  • Elevated natural GH production
  • Improved sleep quality
  • Enhanced muscle recovery
  • Better body composition
  • Anti-aging effects on skin and joints

Best For

Muscle growth Fat loss Anti-aging Sleep improvement General optimization
Note: Best taken on an empty stomach — typically before bed and/or upon waking. Avoid eating 30 minutes before and after. The combination provides a 3-5x greater GH pulse than either peptide alone.

The Shred Stack

Tesamorelin + AOD-9604

moderate evidence

A targeted fat loss stack combining an FDA-approved GHRH analog (Tesamorelin) for visceral fat reduction with a modified HGH fragment (AOD-9604) that stimulates lipolysis without affecting growth or blood sugar.

Goal: Targeted fat loss & body recomposition
Duration: 12-16 weeks
Cost: $60-120/week

Protocol

Peptide Dose Frequency
Tesamorelin 1-2 mg/day 1x daily
AOD-9604 300-500 mcg/day 1x daily (fasted AM)

Benefits

  • Visceral fat reduction
  • Improved body composition
  • No impact on blood sugar
  • Preserved muscle mass
  • Reduced triglycerides

Best For

Stubborn belly fat Contest prep Metabolic health Body recomposition
Note: Tesamorelin has the strongest clinical evidence of any fat-loss peptide (FDA-approved). AOD-9604 adds direct lipolytic action. Both should be administered fasted in the morning for best results.

The Fountain Stack

GHK-Cu + Ipamorelin

moderate evidence

An anti-aging focused stack combining GHK-Cu's gene-level tissue remodeling (4,000+ genes affected) with Ipamorelin's natural GH elevation for comprehensive rejuvenation of skin, joints, and overall vitality.

Goal: Anti-aging, skin health, and vitality
Duration: 12-16 weeks
Cost: $40-70/week

Protocol

Peptide Dose Frequency
GHK-Cu 1-2 mg/day Daily
Ipamorelin 200-300 mcg 1x daily (before bed)

Benefits

  • Improved skin elasticity and texture
  • Reduced fine lines and wrinkles
  • Better sleep quality
  • Joint health support
  • Hair growth support
  • Enhanced wound healing

Best For

Anti-aging protocols Skin rejuvenation Joint health General wellness over 35
Note: GHK-Cu can also be applied topically for localized skin benefits. The combination targets both surface-level skin quality and deep-tissue regeneration via GH elevation.

The Full Send Stack

BPC-157 + TB-500 + Ipamorelin

moderate evidence

The most comprehensive recovery stack, combining the Wolverine Stack with growth hormone support. Covers local tissue repair, systemic healing, and GH-mediated recovery in a single protocol.

Goal: Complete recovery optimization
Duration: 6-10 weeks
Cost: $60-110/week

Protocol

Peptide Dose Frequency
BPC-157 250-500 mcg/day 1-2x daily
TB-500 2 mg 2x weekly
Ipamorelin 200-300 mcg 1x daily (before bed)

Benefits

  • Maximum healing velocity
  • Local + systemic repair
  • Growth hormone-mediated recovery
  • Anti-inflammatory
  • Improved sleep and energy

Best For

Serious injuries Post-surgery rehab Overtraining recovery Competitive athletes in off-season
Note: This is a premium stack best reserved for significant recovery needs. The three peptides address different healing mechanisms for a truly comprehensive approach. Run the BPC-157/TB-500 for 6 weeks with Ipamorelin continuing to 10 weeks.

Metabolic Optimization Stack

The Lean Down

emerging evidence

This stack combines the powerful appetite suppression of Semaglutide with MOTS-c to enhance mitochondrial efficiency and cellular energy. The goal is to maximize fat loss while improving overall metabolic health and energy levels, potentially mitigating some of the fatigue associated with caloric deficits.

Goal: Enhanced Fat Loss & Metabolic Health
Duration: 12 Weeks
Cost: $$$$

Protocol

Peptide Dose Frequency
Semaglutide 0.25-1.0 mg 1x weekly
MOTS-c 5 mg 3x weekly

Benefits

  • Accelerated fat loss
  • Improved insulin sensitivity
  • Enhanced energy during caloric deficit
  • Synergistic metabolic improvement

Best For

Breaking through weight loss plateaus Improving metabolic markers alongside weight loss
Note: Start Semaglutide at the lowest dose (0.25mg) and titrate slowly to assess tolerance. MOTS-c can be administered subcutaneously on non-consecutive days. Monitor for GI side effects from Semaglutide, which are common.

GH Optimization Stack

The Nightcap Stack

moderate evidence

This stack combines a GHRH (Sermorelin) with a GHRP (Ipamorelin) to create a powerful, synergistic effect on the pituitary gland. This dual-action approach results in a stronger, yet still natural, pulse of growth hormone, maximizing benefits for anti-aging, body composition, and recovery without the harsh side effects of synthetic HGH.

Goal: Anti-Aging & Body Recomposition
Duration: 12-16 weeks
Cost: $50-80

Protocol

Peptide Dose Frequency
Sermorelin 100-200 mcg 1x daily (Night)
Ipamorelin 100-200 mcg 1x daily (Night)

Benefits

  • Maximized natural GH release
  • Improved sleep quality and depth
  • Accelerated fat loss
  • Increased lean muscle mass
  • Enhanced skin quality and repair

Best For

Individuals over 30 seeking anti-aging benefits Athletes looking for enhanced recovery Improving sleep and overall vitality
Note: Administer both peptides in the same syringe subcutaneously, 30 minutes before bed on an empty stomach. A 5-on, 2-off weekly protocol is recommended for the duration of the cycle.

The Lean Out Stack

Fat Burner Plus

emerging evidence

This stack combines the direct fat-burning action of AOD-9604 with the systemic metabolic and muscle-preserving benefits of a CJC-1295/Ipamorelin blend. AOD-9604 targets fat cells directly, while the GHS combo elevates growth hormone levels to improve overall metabolism, enhance recovery, and protect lean mass during a caloric deficit.

Goal: Accelerated Fat Loss & Body Recomposition
Duration: 12-16 weeks
Cost: $60-90

Protocol

Peptide Dose Frequency
AOD-9604 300 mcg 1x daily (AM)
CJC-1295 / Ipamorelin 100 mcg / 100 mcg 1x daily (PM)

Benefits

  • Enhanced fat loss
  • Preservation of lean muscle mass
  • Improved sleep and recovery
  • Synergistic metabolic enhancement

Best For

Individuals in a cutting phase Athletes aiming for body recomposition Users wanting fat loss without systemic HGH effects
Note: Administer AOD-9604 in the morning on an empty stomach. Administer CJC/Ipamorelin at night before bed to align with the body's natural GH pulse. Maintain a consistent caloric deficit and training regimen for optimal results.

CJC-1295 + Ipamorelin Stack

The GH Optimizer

moderate evidence

This classic combination leverages the synergy between a long-acting GHRH (CJC-1295) and a potent GHRP (Ipamorelin). CJC-1295 raises the baseline 'bleed' of growth hormone, while Ipamorelin induces strong, clean 'pulses'. The result is a dramatic and sustained increase in overall GH and IGF-1 levels, leading to enhanced muscle growth, fat loss, and recovery.

Goal: Maximize Growth Hormone and IGF-1 for Lean Mass & Fat Loss
Duration: 12-16 weeks
Cost: $50-80

Protocol

Peptide Dose Frequency
CJC-1295 500 mcg 2x per week
Ipamorelin 200-300 mcg 1-2x daily

Benefits

  • Accelerated lean muscle gain
  • Enhanced fat loss
  • Improved sleep quality
  • Faster recovery
  • Anti-aging benefits (skin, joints)

Best For

Athletes seeking performance enhancement Individuals focused on body recomposition Anti-aging protocols
Note: Administer Ipamorelin daily, ideally before bed and/or post-workout on an empty stomach. Administer CJC-1295 on two separate days of the week (e.g., Monday/Thursday). Both are subcutaneous injections and can be administered at the same time if desired.

The Hypertrophy Amplifier Stack

The Growth Stack

emerging evidence

This stack combines a direct growth factor (IGF-1 LR3) with a GHRH/GHRP combination (CJC-1295/Ipamorelin) to create a powerful, multi-faceted anabolic environment. The GHRH/GHRP amplifies the body's natural growth hormone pulses, which increases systemic IGF-1, while IGF-1 LR3 provides a direct, long-acting signal for muscle cell growth and proliferation.

Goal: Maximize Lean Muscle Gain & Recovery
Duration: 8-12 weeks for CJC/Ipamorelin; 4-6 weeks for IGF-1 LR3
Cost: High

Protocol

Peptide Dose Frequency
IGF-1 LR3 50 mcg 1x daily (post-workout)
CJC-1295 (No DAC) 100 mcg 2x daily
Ipamorelin 200 mcg 2x daily

Benefits

  • Accelerated lean mass accrual
  • Enhanced muscle hyperplasia and hypertrophy
  • Improved recovery time
  • Increased fat metabolism

Best For

Experienced users Bulking phases Breaking through strength plateaus
Note: The IGF-1 LR3 is typically cycled for the first 4-6 weeks of the longer CJC/Ipamorelin cycle to kickstart growth. Administer CJC/Ipamorelin on an empty stomach, with one dose before bed. Administer IGF-1 LR3 post-workout with carbohydrates.

GH Fat Loss Synergy Stack

The Visceral Melt

strong evidence

This stack combines a GHRH analogue (Tesamorelin) with a selective GHRP (Ipamorelin) to create a powerful synergistic effect. Tesamorelin initiates the GH pulse, and Ipamorelin amplifies it, resulting in a robust but natural release of growth hormone. This maximizes fat loss, particularly of visceral fat, while minimizing side effects like hunger or cortisol spikes.

Goal: Accelerated Visceral Fat Loss & Improved Body Composition
Duration: 12-16 weeks
Cost: High

Protocol

Peptide Dose Frequency
Tesamorelin 1 mg 1x daily (evening)
Ipamorelin 200-300 mcg 1x daily (evening)

Benefits

  • Maximizes pulsatile GH release
  • Targets stubborn visceral fat
  • Improves body composition
  • Enhances recovery and sleep quality
  • Minimal impact on cortisol and prolactin

Best For

Individuals focused on reducing abdominal fat Users seeking anti-aging benefits from enhanced GH Those wanting to improve metabolic health markers
Note: Administer both peptides in the same syringe subcutaneously in the evening, at least 2 hours after your last meal. This timing aligns with the body's natural GH release cycle during sleep.

The Soviet Stack: Semax & Selank

The Cosmonaut Stack

emerging evidence

This classic nootropic combination pairs the stimulating, focus-enhancing properties of Semax with the calming, anxiolytic effects of Selank. The result is a state of calm, clear-headed focus, reduced anxiety, and enhanced cognitive endurance without overstimulation or jitters.

Goal: Enhanced cognitive function and mood stabilization
Duration: 2-4 week cycles
Cost: $40-70

Protocol

Peptide Dose Frequency
Semax 200-500 mcg 1-2x daily (AM)
Selank 250-500 mcg 1-2x daily

Benefits

  • Calm, focused mental state
  • Reduced anxiety and stress
  • Improved memory and learning
  • Enhanced mood and motivation

Best For

High-pressure work or study Individuals prone to anxiety Creative problem-solving
Note: Administer both peptides as nasal sprays. It's common to take Semax in the morning for focus and use Selank either concurrently or in the afternoon/evening to manage stress and promote relaxation.

The Gut Repair Protocol

Gut Guardian

moderate evidence

This stack combines the structural healing of BPC-157 with the potent anti-inflammatory action of KPV. It is designed to address both the symptoms (inflammation) and root causes (compromised intestinal lining) of gut dysfunction.

Goal: Gut Healing & Inflammation Control
Duration: 4-8 weeks
Cost: ~$50-80

Protocol

Peptide Dose Frequency
BPC-157 250 mcg 2x daily (oral)
KPV 250 mcg 2x daily (oral)

Benefits

  • Reduces gut inflammation
  • Supports healing of intestinal lining
  • Alleviates symptoms of IBD & leaky gut
  • Improves nutrient absorption

Best For

Individuals with IBD or IBS Those with 'leaky gut' syndrome Post-antibiotic gut recovery General gut health optimization
Note: For best results, both peptides should be taken orally as they are stable in gastric acid. Take on an empty stomach for optimal absorption.

The CagriSema Protocol

Ultimate Weight Loss

strong evidence

This advanced stack combines Cagrilintide, an amylin analogue, with Semaglutide, a GLP-1 agonist. They work on separate but complementary pathways in the brain and gut to create a powerful synergistic effect, drastically reducing appetite and promoting significant weight loss beyond what either peptide can achieve alone.

Goal: Maximum Weight Loss & Appetite Control
Duration: 20-52 weeks
Cost: $$$$ (Very High)

Protocol

Peptide Dose Frequency
Cagrilintide 0.3mg - 2.4mg, titrated 1x weekly
Semaglutide 0.25mg - 2.4mg, titrated 1x weekly

Benefits

  • Maximal appetite suppression
  • Synergistic and accelerated weight loss
  • Improved glycemic control
  • Reduced food cravings and 'food noise'

Best For

Individuals with significant weight to lose Those who have plateaued on GLP-1 agonists alone Users seeking the most potent research-backed weight loss stack
Note: Both peptides are administered once weekly via subcutaneous injection. They can be injected at the same time, but at different sites. Slow dose titration for both compounds is critical to manage side effects, particularly nausea. This is an advanced protocol.

GH Synergy Stack

The Classic GH Combo

strong evidence

This stack combines a GHRH (CJC-1295) with a GHRP (GHRP-6) to create a powerful synergistic effect on growth hormone release. GHRP-6 initiates a strong GH pulse, and CJC-1295 amplifies it, resulting in a release that is significantly greater than either peptide could achieve alone. This mimics the body's natural feedback loops for maximal effect.

Goal: Maximize Growth Hormone Release for Muscle Growth & Recovery
Duration: 8-12 weeks
Cost: $40-70

Protocol

Peptide Dose Frequency
CJC-1295 (No DAC) 100 mcg 1-3x daily
GHRP-6 100 mcg 1-3x daily

Benefits

  • Maximal GH and IGF-1 increase
  • Accelerated muscle growth
  • Enhanced fat loss
  • Improved recovery and sleep

Best For

Bulking phases Users seeking significant mass gain Experienced peptide researchers
Note: Both peptides can be drawn into the same syringe. Must be administered on an empty stomach. The strong appetite stimulation from GHRP-6 makes this stack ideal for bulking.

GH Max Pulse Stack

The Heavy Hitter

moderate evidence

This stack combines the most potent synthetic GHRP, Hexarelin, with a powerful GHRH, CJC-1295 without DAC. CJC-1295 amplifies the GH pulse initiated by Hexarelin, resulting in a maximal, synergistic release of growth hormone from the pituitary. This combination is researched for dramatic increases in GH and IGF-1 for short, intensive cycles.

Goal: Maximum increase in GH/IGF-1 for muscle growth and fat loss
Duration: 4-8 weeks on, 4-8 weeks off
Cost: Medium

Protocol

Peptide Dose Frequency
Hexarelin 100 mcg 1-2x daily
CJC-1295 (No DAC) 100 mcg 1-2x daily

Benefits

  • Synergistic, maximal GH release
  • Accelerated lean muscle accrual
  • Enhanced fat loss (lipolysis)
  • Improved recovery and sleep quality

Best For

Experienced researchers Short-term massing cycles Breaking through plateaus
Note: Administer both peptides in the same syringe on an empty stomach, typically before bed and/or post-workout. Due to Hexarelin's desensitization and cortisol/prolactin effects, this stack is not for beginners or long-term use.

GH Amplification Stack

The Classic Pulse

moderate evidence

This stack combines a GHRH (CJC-1295 No DAC) with a GHRP (GHRP-2) to create a powerful, synergistic release of growth hormone. CJC-1295 increases the number of GH-releasing cells and the amount they can release, while GHRP-2 strongly signals for that release to happen. The combination results in a GH pulse far greater than either compound could achieve alone.

Goal: Maximize natural GH release for lean mass and fat loss.
Duration: 8-12 weeks
Cost: $40-60

Protocol

Peptide Dose Frequency
GHRP-2 100 mcg 2-3x daily
CJC-1295 (No DAC) 100 mcg 2-3x daily

Benefits

  • Synergistic increase in GH and IGF-1
  • Accelerated lean muscle accrual
  • Enhanced fat metabolism
  • Improved recovery and sleep quality

Best For

Bodybuilders in a lean gaining phase Individuals seeking anti-aging benefits Athletes focused on recovery
Note: Administer both peptides in the same syringe on an empty stomach to maximize the pulse. Timing around workouts and before bed is optimal.

Immune & Repair Stack

The Defender

emerging evidence

This stack combines the potent immunomodulatory and antimicrobial power of LL-37 with the systemic tissue repair capabilities of BPC-157. LL-37 acts as the first responder to clear infection and manage initial inflammation, while BPC-157 works to accelerate the healing of damaged tissues, from gut lining to connective tissues.

Goal: Accelerated recovery from injury or infection
Duration: 2-4 weeks
Cost: $100-150

Protocol

Peptide Dose Frequency
LL-37 100-200 mcg 1x daily
BPC-157 250 mcg 2x daily

Benefits

  • Fights infection at injury sites
  • Reduces systemic inflammation
  • Accelerates healing of skin, muscle, and gut
  • Supports a balanced immune response

Best For

Post-surgery recovery Healing chronic or infected wounds Supporting gut health during dysbiosis Soft tissue injuries with high infection risk
Note: Administer as separate subcutaneous injections. It is common to inject BPC-157 closer to an injury site, while LL-37 can be injected systemically (e.g., abdomen). The LL-37 cycle should remain short-term.

The Immune Resilience Stack

Immune & Gut Fortifier

emerging evidence

This stack combines a primary immune modulator (Thymosin Alpha-1) with a systemic healing and gut repair agent (BPC-157). The goal is to strengthen both the cellular immune response and the physical barriers of the immune system, such as the gut lining, for comprehensive defense.

Goal: Comprehensive Immune Support & Gut Health
Duration: 8 weeks
Cost: ~$50-75

Protocol

Peptide Dose Frequency
Thymosin Alpha-1 600 mcg 3x weekly
BPC-157 250 mcg 2x daily

Benefits

  • Enhanced response to pathogens
  • Improved gut barrier function
  • Reduced systemic inflammation
  • Support for autoimmune balance

Best For

Individuals with frequent illnesses Support during cold & flu season Those with compromised gut health
Note: BPC-157 can be taken orally for gut-specific effects or subcutaneously for systemic action. TA1 is administered subcutaneously. Doses can be adjusted based on individual response and research protocol.

Ultimate GH Stack

The Growth Maximizer

emerging evidence

This stack combines the long-acting, steady GH elevation from oral MK-677 with the sharp, biomimetic pulse from injectable CJC-1295 and Ipamorelin. The result is a powerful, synergistic effect that significantly elevates both baseline and peak GH and IGF-1 levels, maximizing benefits for muscle growth, fat loss, and recovery.

Goal: Maximize lean muscle growth and accelerate recovery
Duration: 8-12 weeks
Cost: $70-120

Protocol

Peptide Dose Frequency
MK-677 15-25 mg 1x daily (at night)
CJC-1295 (No DAC) 100 mcg 1-2x daily
Ipamorelin 200-300 mcg 1-2x daily

Benefits

  • Significant increase in lean muscle mass
  • Accelerated fat loss
  • Dramatically improved recovery
  • Enhanced sleep quality and depth
  • Improved skin elasticity and hair health

Best For

Experienced users seeking maximum muscle growth Athletes in an off-season or bulking phase Advanced anti-aging protocols
Note: Inject CJC-1295/Ipamorelin blend subcutaneously on an empty stomach, at least 1-2 hours away from meals. A common protocol is one injection post-workout and another before bed. Take the oral MK-677 dose with the pre-bed injection.