Melanotan II
(Ac-Nle4, Asp5, D-Phe7, Lys10)α-MSH4-10-NH2
The synthetic tanning peptide that darkens skin and boosts libido.
Melanotan II is a synthetic analog of the naturally occurring alpha-melanocyte-stimulating hormone (α-MSH). Originally developed at the University of Arizona for its potential as a sunless tanning agent, it stimulates the body's natural pigmentation process. Beyond tanning, it has become well-known for its potent effects on libido and appetite suppression.
Key Benefits
Mechanism of Action
Melanotan II functions as a non-selective agonist for melanocortin receptors (MC1, MC3, MC4, MC5). Its binding to the MC1 receptor on melanocytes stimulates the production and release of melanin, leading to skin pigmentation (tanning). Activation of the MC4 receptor in the brain is primarily responsible for its well-documented effects on increasing sexual arousal and suppressing appetite.
Dosing Guidelines
Typical Dose
100-500 mcg
Frequency
Daily or every other day
Duration
2-4 week loading phase, then as-needed maintenance
Note: Administer subcutaneously. Start with a very low dose (e.g., 100 mcg) to assess nausea. Injecting at night can help mitigate initial side effects. Combine with brief sun exposure to accelerate tanning.
Research & Studies
A comprehensive overview of Melanotan II's action on melanocortin receptors and its researched effects on tanning, libido, and appetite.
Read Full ResearchClinical trial data exploring the peptide's ability to induce erections and increase sexual desire in both men and women via MC4R activation.
Read Full ResearchExamines the role of increased eumelanin production stimulated by Melanotan II in protecting the skin against UV-induced damage.
Read Full ResearchPotential Side Effects
Reported side effects may include:
- • Nausea (common, especially at first)
- • Facial flushing immediately after injection
- • Spontaneous erections in males
- • Darkening of existing moles and development of new freckles
- • Appetite suppression (can be desired or undesired)
- • Yawning, stretching, and fatigue
This information is for research purposes only. Always consult with a healthcare professional.
Popular Stacking Options
Melanotan II + Ipamorelin / CJC-1295
Combines the aesthetic and libido benefits of MT-II with the systemic anti-aging, recovery, and body composition effects of a GHRH/GHRP cycle.
Shop this stackMelanotan II + BPC-157
Creates a 'look and feel good' protocol by pairing MT-II's external benefits with the internal healing, gut health, and anti-inflammatory properties of BPC-157.
Shop this stackMelanotan II + GHK-Cu
Forms a powerful skin health stack. MT-II increases melanin for color and protection, while GHK-Cu promotes collagen synthesis and skin repair for improved texture and tone.
Shop this stackFrequently Asked Questions
How long does it take for Melanotan II to start working?
Tanning effects are gradual and user-dependent. Most people notice a visible change in skin tone after 1-3 weeks of consistent use, especially when paired with some UV exposure. The aphrodisiac effects can be felt much faster, often within hours of the first few injections.
Is the tan from Melanotan II permanent?
No, it's not permanent. The tan lasts as long as you continue to use the peptide at a maintenance dose. Once you stop, your skin will gradually return to its natural baseline color over several weeks to months as your skin cells naturally turn over.
How can I avoid the nausea from Melanotan II?
Nausea is the most common side effect but it usually gets better. The best strategy is to start with a very low dose, around 100 mcg, and see how you feel. Injecting right before bed can also help you sleep through the worst of it. Don't rush to increase your dose.
Will Melanotan II really make my moles darker?
Yes, it almost certainly will. Because it stimulates all melanocytes, it will darken existing moles, freckles, and other pigmented spots. It can also cause new, small, dark freckles to appear. This is a crucial side effect to be aware of before starting.
What's the difference between Melanotan I and Melanotan II?
Melanotan I (Afamelanotide) is more selective for the MC1 receptor, so its main effect is skin tanning with far fewer side effects. Melanotan II is non-selective and hits multiple receptors, which is why it causes tanning (MC1R) plus the strong libido enhancement and appetite suppression (MC4R).
Ready to Purchase Melanotan II?
Get pharmaceutical-grade Melanotan II from Peptide Palace with 99%+ purity, third-party lab testing, and same-day dispatch.
Buy Melanotan II Now