Dosing Protocols for Peptides

Introduction

Proper dosing is critical for achieving desired results while minimizing side effects. This guide provides comprehensive dosing protocols based on available evidence and practitioner experience.

General Dosing Principles

Start Low, Go Slow

• Begin at lowest effective dose
• Titrate up based on response
• Allow 2-4 weeks between increases
• Monitor for side effects at each level

Individual Variation

Factors affecting optimal dose:

• Body weight and composition
• Age and metabolic rate
• Receptor sensitivity
• Previous peptide use
• Concurrent medications
• Health status

Growth Hormone Releasing Peptides (GHRPs)

GHRP-2

Timing: Upon waking, post-workout, before bed Notes: Stimulates appetite; may increase cortisol at high doses

GHRP-6

Timing: 30 minutes before meals (enhances appetite) Notes: Strongest hunger effect of GHRPs

Ipamorelin

Timing: Upon waking, post-workout, before bed Notes: Cleanest GHRP; minimal appetite/cortisol effects

Hexarelin

Notes: Rapid desensitization; limit to 4-8 weeks

Growth Hormone Releasing Hormones (GHRHs)

CJC-1295 (with DAC)

Timing: Consistent weekly schedule Notes: Sustained GH elevation; pair with GHRP for pulse

CJC-1295 (no DAC) / Mod GRF 1-29

Timing: Same timing as paired GHRP Notes: Always use with GHRP for best results

Sermorelin

Timing: Before bed (mimics natural GH pulse) Notes: Gentler profile; good for beginners

Recovery Peptides

BPC-157

Administration: Subcutaneous or intramuscular (near injury) Notes: Can use orally for gut issues; injectable for systemic

TB-500

Administration: Subcutaneous or intramuscular Notes: Systemic effects; loading phase important

Metabolic Peptides

Tesamorelin

Timing: Morning or evening, consistent timing Notes: FDA-approved for lipodystrophy

MOTS-c

Timing: Training days; some prefer fasted Notes: Emerging peptide; dosing still being optimized

HGH Fragment 176-191

Timing: Fasted states (morning, before bed) Notes: Fat-specific; no GH effects on glucose

Stacking Protocols

GH Secretagogue Stack

Recovery Stack

Fat Loss Stack

Injection Technique Optimization

Subcutaneous Administration

• Rotate injection sites (abdomen, thigh, deltoid)
• Use 29-31 gauge insulin needles
• Inject at 45-90 degree angle
• Clean site with alcohol
• Allow alcohol to dry before injection

Timing Considerations

Reconstitution Guidelines

Bacteriostatic Water Volumes

Storage After Reconstitution

• Refrigerate at 36-46°F (2-8°C)
• Use within 3-4 weeks
• Avoid freezing reconstituted peptides
• Protect from light

Conclusion

Proper dosing requires attention to individual response, careful titration, and consistent administration. Start conservatively, monitor closely, and adjust based on results and side effects.